Introduction
Nasopharyngeal Carcinoma (NPC) incidence is significantly lower compared to endemic geographic regions such as East and Southeast Asian. A 10-year retrospective analysis was conducted for all patients that were treated for NPC at St. James’ University hospital.
Material and Method
65 patients were included in the study for analysis. Patient demographics, disease histopathology, staging, treatment modality, recurrence, and salvage treatment were obtained. Kaplan Meier curves were used to assess survival. Cox regression analyses were also conducted to examine prognostic factors for NPC.
Results
Average age was 53 years, with a 43-month median follow-up time. Majority (60%, n=39) of the patients were EBV positive. A large majority (73.8%, n=48) presented with locally advanced disease. 72.3% of patients (n=47) received Chemoradiotherapy treatment initially. Nearly a quarter of the patients (n=16) had disease recurrence on post-treatment follow-up. Age at diagnosis and keratinising histopathological subtype were the factors that significantly influenced long-term patient prognosis (P<0.05).
Conclusion
There is currently a lack of literature that examines NPC in non-endemic settings. This study looks to fill this gap in knowledge and examines the NPC in Ireland, a non-endemic area. We also highlight the factors correlated with long-term survival for NPC in a non-endemic population.
Abidur Rahman1, E Finnegan1, S Celli1, H Alsubaie1, Justin Hintze1, Paul Lennon1, John Kinsella1, Conrad Timon1, Shawkat Abdulrahman1, Conall Fitzgerald1
1 Department of Otolaryngology, Head & Neck Surgery, St. James’s University Hospital, Dublin