Ryan O’Sullivan 1 , Deirdre Callanan 1 , Hadeel Jawad 2 , David Brinkman 1 ,Ross O’Shea 1 , Andrew Dias 1 , Linda Feeley 2 , Patrick Sheahan 1 1. Department of Otorhinolaryngology/Head, Neck Surgery, South Infirmary Victoria University Hospital, Cork. 2. Department of Pathology Department, Cork University Hospital, Cork
Background: Oral Cavity Cancer (OCC) is reported to account for ~2% of all diagnosed malignancies and 40% of Head and Neck cancers. In patients who have been treated for OCC, second primary tumours (SPT) are a leading cause of morbidity and mortality. This study analyses the patterns of SPT post OCC.
Methods: Retrospective study of 359 patient who underwent surgical management of OCC over a 21-year period. Review of the clinical notes and histopathology was undertaken to allow analysis of the rates, risk factors and trends of recurrence.
Results: There were 30(8.4%) cases of head and neck second primary (H&N SPT). The most common site was oropharynx (n=8, 26.6%). Death attributable to disease occurred in 13.3%(n=4) with mean follow-up: 9.2yr. There were 52 cases non-H&N second primary (14.5%). Lung was the most common subsite (n=26, 50%). Mean time to second primary was 4.5yr. There were 4 cases of recurrent SPT H&N tumour (13%).No statistically significant association was identified between H&N SPT”™s and primary tumour margin status (p=0.99), tumour size (p=0.507), radiotherapy status (p=.67), or AJCC 8th edition stage (p=0.1). Conclusion: OCC are at high risk of SPT. This emphasises the importance of clinical screening for SPT during surveillance visits.